Sleep awakens active expiration

Sleep apnea awakens cancer

Obstructive sleep apnea syndrome (OSA) is a highly prevalent disorder affecting approximately 4 to 10% of adults that has been implicated in a large spectrum of end-organ morbidities. OSA is characterized by repetitive obstructions of the upper airway during sleep that result in intermittent hypoxia (IH), increased inspiratory efforts, and ultimately sleep fragmentation (SF). A large body of re...

NMR spectroscopy: Chemistry awakens a silent giant.

The iPSC Awakens ANGPTL3 in Tangier Disease

Patients with genetic mutation of ATP-binding Cassette Transporter A1 (ABCA1), commonly known as Tangier Disease (TD), can be characterized by elevated levels of plasma triglycerides (hypertriglyceridemia) and low plasma high-density lipoprotein (HDL) levels. With current HDL therapies continuously failing in clinical trials, there is no cure for TD other than maintaining a very low fat diet. T...

The Sleeping Giant Awakens

Perhaps the defining issue of our time in history is the emergence of India and the People’s Republic of China as regional military superpowers. This is a direct by-product of large scale industrialisation, as the economies of these billion plus population base nations are able to support increasingly large and modern military force structures. Spare cash and national pride are often a volatile...

Sleep-Active Neurons: Conserved Motors of Sleep

Sleep is crucial for survival and well-being. This behavioral and physiological state has been studied in all major genetically accessible model animals, including rodents, fish, flies, and worms. Genetic and optogenetic studies have identified several neurons that control sleep, making it now possible to compare circuit mechanisms across species. The "motor" of sleep across animal species is f...